influence of three morus species extracts on ?-amylase activity
نویسندگان
چکیده
diabetes mellitus is one of the most common endocrine diseases and its type ii is the major form of diabetes, accounting for 90% of cases worldwide. the inhibition of carbohydrate hydrolyzing enzymes such as ?-amylase can be an important strategy in the control of blood glucose levels in patients with type ii diabetes. in this investigation, three morus species, m. alba, m. alba var. nigra and m. nigra, were studied for their possible effects on the starch breakdown by ?-amylase in vitro. m. alba var. nigra [ic50=13.26 (12.86-13.66) mg/ml] and m. alba [ic50=17.60 (17.39-17.80) mg/ml] revealed appreciable ?-amylase inhibitory activities in a concentration-dependent manner. furthermore, the most active extract (i.e. m. alba var. nigra,) was partitioned by stepwise solvent-solvent extraction process and the inhibitory activities of each of the fractions on the enzyme were studied. according to the results, all the fractions (n-hexane, chloroform, ethyl acetate and aqueous fractions) had potent inhibitory effects on the ?-amylase activity. however, the lowest inhibitory potency was observed for the aqueous fraction.
منابع مشابه
Influence of Three Morus Species Extracts on ?-Amylase Activity
Diabetes mellitus is one of the most common endocrine diseases and its type II is the major form of diabetes, accounting for 90% of cases worldwide. The inhibition of carbohydrate hydrolyzing enzymes such as ?-amylase can be an important strategy in the control of blood glucose levels in patients with type II diabetes. In this investigation, three Morus species, M. alba, M. alba var. nigra and ...
متن کاملInfluence of Three Morus Species Extracts on ?-Amylase Activity
Diabetes mellitus is one of the most common endocrine diseases and its type II is the major form of diabetes, accounting for 90% of cases worldwide. The inhibition of carbohydrate hydrolyzing enzymes such as ?-amylase can be an important strategy in the control of blood glucose levels in patients with type II diabetes. In this investigation, three Morus species, M. alba, M. alba var. nigra and ...
متن کاملInhibitory Effects of Six Allium Species on ?-Amylase Enzyme Activity
Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia. The management of the blood glucose level is a critical strategy in the control of diabetes complications. Inhibitors of carbohydrate hydrolyzing enzymes have been useful as oral hypoglycemic drugs for the control of hyperglycemia especially in patients with type II disables mellitus. The goal of the present study...
متن کاملInhibitory Effects of Six Allium Species on ?-Amylase Enzyme Activity
Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia. The management of the blood glucose level is a critical strategy in the control of diabetes complications. Inhibitors of carbohydrate hydrolyzing enzymes have been useful as oral hypoglycemic drugs for the control of hyperglycemia especially in patients with type II disables mellitus. The goal of the present study...
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عنوان ژورنال:
iranian journal of pharmaceutical researchجلد ۲۰۰۹، شماره ۴، صفحات ۱۱۵-۱۱۹
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